5/17/2025
Last update
5/17/2025
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin E (as d-alpha Tocopherol)
268 mg
1787%
Top Medical Research Studies
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Read More
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
Read More
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
Read More
Most Useful Reviews
9
Blood viscosity improvement
My blood tests showed that I had thick blood, posing a risk for thrombosis. After drinking this Vitamin E for a month, my blood has become thinner, even below the normal range!
Read More
6
Family health support
1 people found this helpful
I purchased this Vitamin E on the recommendation of Tokumi Fujikawa. It not only helps prevent blood clots but is now taken daily by my entire family, including my children with arrhythmia.
Read More
6
Reliable vitamin E source
1 people found this helpful
My husband takes a daily vitamin E supplement from Now. We trust their products for their quality and transparency in ingredients. This particular formula offers d-alpha tocopherol, the most active form of vitamin E, which is beneficial for nerve and muscle function, prevents blood clots, and boosts immunity. The once-a-day softgel provides great value with a three-month supply.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.4
- All Researches
9
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
Read More
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Read More
9
We explored the effects of vitamin E and sesamin on blood pressure and blood clot formation using young rats prone to stroke. The rats were divided into four groups: a control group, a vitamin E group, a sesamin group, and a combination group for five weeks.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
Notably, the rats receiving vitamin E and sesamin showed lower blood pressure and thrombotic tendencies compared to the control group. However, while there was some reduction in clot formation, it was not substantial enough to conclude a significant clinical benefit.
Thus, we observed that while vitamin E and sesamin may have some protective effects, their impact on blood clot prevention is not definitively established.
Read More
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
Read More
8
We explored how inducing heme oxygenase-1 (HO-1) could impact blood clot formation in a mouse model. Through a series of tests, we observed that mice treated with a HO-1 inducer showed a significant delay in thrombus formation.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
This effect was linked to the production of bilirubin and carbon monoxide, which have protective roles in the bloodstream. Interestingly, when we used a vitamin E analogue, it almost entirely restored this delay in clotting. Overall, these findings suggest that enhancing HO-1 activity may offer a promising approach to prevent undesirable blood clots.
Read More
User Reviews
USERS' SCORE
Moderately Good
Based on 9 Reviews
7.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Blood viscosity improvement
My blood tests showed that I had thick blood, posing a risk for thrombosis. After drinking this Vitamin E for a month, my blood has become thinner, even below the normal range!
Read More
6
Family health support
1 people found this helpful
I purchased this Vitamin E on the recommendation of Tokumi Fujikawa. It not only helps prevent blood clots but is now taken daily by my entire family, including my children with arrhythmia.
Read More
6
Reliable vitamin E source
1 people found this helpful
My husband takes a daily vitamin E supplement from Now. We trust their products for their quality and transparency in ingredients. This particular formula offers d-alpha tocopherol, the most active form of vitamin E, which is beneficial for nerve and muscle function, prevents blood clots, and boosts immunity. The once-a-day softgel provides great value with a three-month supply.
Read More
7.5
Lowered blood pressure
My blood pressure had been high for some time, but after three months of taking it, it dropped and I experienced no issues during my health check-ups.
Read More
7.5
Enhanced resistance
After taking E400, I noticed improved bodily resistance and benefits for my blood vessels, all at a reasonable price.
Read More
Frequently Asked Questions
9
Blood viscosity improvement
My blood tests showed that I had thick blood, posing a risk for thrombosis. After drinking this Vitamin E for a month, my blood has become thinner, even below the normal range!
7.5
Lowered blood pressure
My blood pressure had been high for some time, but after three months of taking it, it dropped and I experienced no issues during my health check-ups.
2
Monitor dosage
1 people found this helpful
It thins the blood! I've been taking it for about two months, but now my blood doesn’t clot as easily when I get injured. I will reduce my intake and monitor the effects. It’s excellent for thinning the blood.
7.5
Enhanced resistance
After taking E400, I noticed improved bodily resistance and benefits for my blood vessels, all at a reasonable price.
7.5
Effective blood smoothness
3 people found this helpful
Since taking two capsules daily, I've noticed an improvement in blood smoothness. The benefits are evident, but I advise caution if you're on anticoagulants such as warfarin.
6
Family health support
1 people found this helpful
I purchased this Vitamin E on the recommendation of Tokumi Fujikawa. It not only helps prevent blood clots but is now taken daily by my entire family, including my children with arrhythmia.
6
Caution with clots
2 people found this helpful
Vitamin E is crucial for rejuvenating skin and blood vessels. It makes skin firm and improves blood flow. However, those with blood clots should be cautious, as excessive Vitamin E could exacerbate clot issues.
9
We investigated whether vitamin E supplementation affects the risk of blood clots, specifically venous thromboembolism (VTE), in women. The Women's Health Study involved nearly 40,000 women who received either vitamin E or a placebo over more than ten years.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
Our findings revealed that those taking vitamin E experienced a significant reduction in VTE occurrences compared to the placebo group. Notably, women with a history of VTE or certain genetic factors benefited the most from supplementation.
Overall, vitamin E may play a protective role against blood clots, offering promise for at-risk individuals.
9
We explored how vitamin E affects blood clot breakdown in patients suffering from coronary spastic angina. In a well-structured study, 40 participants were split into groups receiving either vitamin E or a placebo over a month.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
We observed that those who took vitamin E experienced significant improvements, with decreased levels of a key clotting factor and a marker for oxidative stress. This suggests that vitamin E may serve as an effective addition to treatments for managing coronary spasms, especially in patients without coronary atherosclerosis.
7
We examined how vitamin E influences bleeding risks in patients with nonvalvular atrial fibrillation undergoing anticoagulant therapy. In our retrospective study of 566 patients, higher levels of serum vitamin E were associated with increased bleeding events.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
Specifically, those who experienced bleeding had significantly higher vitamin E concentrations compared to those who did not. This suggests that elevated vitamin E may predict a higher risk of hemorrhage in patients taking anticoagulants, prompting the need for further research to clarify this relationship with newer medications.
7
Vitamins reduce nicotine-induced clotting
This study focused on how nicotine affects blood clotting in mouse brain microvessels and the potential protective role of vitamins C and E.
We observed that nicotine treatment significantly sped up platelet aggregation in arterioles, making the mice more prone to clots.
However, when combined with vitamins C or E, this effect was notably reduced, demonstrating that these vitamins can help counteract nicotine’s harmful impact on blood vessels.
Importantly, neither vitamin alone showed protective effects without the presence of nicotine.
We observed that nicotine treatment significantly sped up platelet aggregation in arterioles, making the mice more prone to clots.
However, when combined with vitamins C or E, this effect was notably reduced, demonstrating that these vitamins can help counteract nicotine’s harmful impact on blood vessels.
Importantly, neither vitamin alone showed protective effects without the presence of nicotine.
7
We examined whether vitamin E, alongside astaxanthin, could help prevent blood clots and hypertension in stroke-prone rats. For three weeks, groups of male rats received either vitamin E or astaxanthin, while we monitored their response.
Though both treatments showed promise, particularly in improving nitric oxide levels and lowering oxidative damage, the findings suggest that vitamin E alone may not provide significant benefits in reducing thrombosis. Astaxanthin demonstrated more robust protective effects in this study.
Though both treatments showed promise, particularly in improving nitric oxide levels and lowering oxidative damage, the findings suggest that vitamin E alone may not provide significant benefits in reducing thrombosis. Astaxanthin demonstrated more robust protective effects in this study.
9
Our exploration focused on how tocotrienols, a form of vitamin E, influence blood clotting, especially in the context of risk factors like stroke. Using a canine model, we assessed the effects of tocotrienols on platelet aggregation and thrombus formation.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
The findings revealed that tocotrienols significantly inhibited both platelet thrombus formation and collagen-induced platelet aggregation. We noticed that tocotrienols could be converted to tocopherols, which might add to their effectiveness. Overall, these results suggest tocotrienols could offer a therapeutic advantage in preventing serious cardiovascular events.
References
- Jafar Haeri SM, Dashti G, Mardani M, Rashidi B, Nikgoftar Fathi A, et al. Effect of Vitamin E on Apoptosis of the Endothelial Cells of the Carotid Arteries in Hypercholesterolemic Male Rabbits. ARYA Atheroscler. 2023;19:10. 10.48305/arya.2022.39175.2824
- Ho JI, Ng EY, Chiew Y, Koay YY, Chuar PF, et al. The effects of vitamin E on non-proliferative diabetic retinopathy in type 2 diabetes mellitus: Are they sustainable with 12 months of therapy. SAGE Open Med. 2022;10:20503121221095324. 10.1177/20503121221095324
- Ceran C, Aksam E, Aksam B, Yenidünya S, Suludere Z, et al. Tamoxifen-Related Thrombosis: An Experimental Study in Rat Venous Microvascular Anastomosis Model. Ann Plast Surg. 2017;78:213. 10.1097/SAP.0000000000000798
- Pastori D, Carnevale R, Cangemi R, Saliola M, Nocella C, et al. Vitamin E serum levels and bleeding risk in patients receiving oral anticoagulant therapy: a retrospective cohort study. J Am Heart Assoc. 2013;2:e000364. 10.1161/JAHA.113.000364
- Sasaki Y, Kobara N, Higashino S, Giddings JC, Yamamoto J. Astaxanthin inhibits thrombosis in cerebral vessels of stroke-prone spontaneously hypertensive rats. Nutr Res. 2011;31:784. 10.1016/j.nutres.2011.09.010
- Fahim MA, Nemmar A, Singh S, Hassan MY. Antioxidants alleviate nicotine-induced platelet aggregation in cerebral arterioles of mice in vivo. Physiol Res. 2011;60:695.
- Qureshi AA, Karpen CW, Qureshi N, Papasian CJ, Morrison DC, et al. Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries. Lipids Health Dis. 2011;10:58. 10.1186/1476-511X-10-58
- Ristow B. Preoperative use of alpha tocopherol does not increase the risk of hematoma in the face lift patient: a preliminary report. Plast Reconstr Surg. 2009;124:1696. 10.1097/PRS.0b013e3181b98a3a
- Ping-Chia L, I-Ju L, Yu-Ching L, Li-Ching C, Wen-Chung C. Substance P scavenger enhances antioxidant defenses and prevents prothrombotic effects on the rat lung after acute exposure to oil smoke. J Biomed Sci. 2009;16:58. 10.1186/1423-0127-16-58
- Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. 2007;116:1497.
- Singh I, Turner AH, Sinclair AJ, Li D, Hawley JA. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr. 2007;16:422.
- Allman-Farinelli MA, Dawson B. Diet and aging: bearing on thrombosis and hemostasis. Semin Thromb Hemost. 2005;31:111.
- Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Yamori Y. Effects of vitamin E and sesamin on hypertension and cerebral thrombogenesis in stroke-prone spontaneously hypertensive rats. Clin Exp Pharmacol Physiol. 2004;31 Suppl 2:S24.
- Miyamoto S, Kawano H, Takazoe K, Soejima H, Sakamoto T, et al. Vitamin E improves fibrinolytic activity in patients with coronary spastic angina. Thromb Res. 2004;113:345.
- Lindenblatt N, Bordel R, Schareck W, Menger MD, Vollmar B. Vascular heme oxygenase-1 induction suppresses microvascular thrombus formation in vivo. Arterioscler Thromb Vasc Biol. 2004;24:601.
